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The antibody against TDRD3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TDRD3 (NP_110421.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TDRD3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TDRD3 (NP_110421.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03609A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TDRD3 |
| Target Synonyms | TDRD3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | U2OS | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TDRD3 (NP_110421.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H7E2 | Immunogen Sequence |
Uniprot Id
Q9H7E2
Target Species
Human
Target Name
TDRD3
Target Full Name
Tudor domain-containing protein 3
Target Function
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Tissue Specificity
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Target Synonyms
4732418C03Rik; 6720468N18; FLJ21007; OTTHUMP00000018485; TDRD 3; tdrd3; TDRD3_HUMAN; Tudor domain containing 3; Tudor domain containing protein 3; Tudor domain-containing protein 3
Target Background
Enables chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in chromatin organization and positive regulation of transcription, DNA-templated. Located in Golgi apparatus; cytosol; and nucleoplasm. Colocalizes with exon-exon junction complex.
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