Rabbit anti-Human TrKC Polyclonal Antibody

Uniprot Id

Q16288

Target Species

Human

Target Name

NTRK3

Target Full Name

NT-3 growth factor receptor

Target Function

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Target Involvement

Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily

Target Tissue Specificity

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Target Synonyms

EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETS related protein neurotrophic receptor tyrosine kinase fusion protein; ETV6 NTRK3 fusion ; GP145 TrkC ; gp145(trkC) ; GP145-TrkC; GP145TrkC ; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor ; NT 3 growth factor receptor ; NT 3 growth factor receptor precursor ; NT 3 receptor; NT-3 growth factor receptor; Ntrk3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; Trk-C; TRKC; TrkC tyrosine kinase; Tyrosine kinase receptor C

Target Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.