Rabbit anti-Human SMPD4 Polyclonal Antibody

Uniprot Id

Q9NXE4

Target Species

Human

Target Name

SMPD4

Target Full Name

Sphingomyelin phosphodiesterase 4

Target Function

Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Nucleus envelope. Cell membrane, sarcolemma.

Target Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle.; [Isoform 1]: Expressed in skeletal muscle (at protein level).; [Isoform 2]: Expressed in skeletal muscle but a lower levels than isoform 1 (at protein level).

Target Synonyms

EC 3.1.4.12; EC=3.1.4.123; FLJ20297; FLJ20756; KIAA1418; NET 13; NET13; Neutral sphingomyelinase 3; Neutral sphingomyelinase III; NSMA3_HUMAN; nSMase 3; nSMase-3; nSMase3; OTTHUMP00000162391; OTTHUMP00000190862; SKNY protein; smpd4; Sphingomyelin phosphodiesterase 4; Sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase 3)

Target Background

The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.