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The antibody against DEF6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-330 of human DEF6 (NP_071330.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DEF6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-330 of human DEF6 (NP_071330.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05706A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DEF6 |
| Target Synonyms | IBP; SLAT; IMD87; SWAP70L; DEF6 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain, Mouse thymus, Rat spleen, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 60-330 of human DEF6 (NP_071330.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H4E7 | Immunogen Sequence |
Uniprot Id
Q9H4E7
Target Species
Human
Target Name
DEF6
Target Full Name
Differentially expressed in FDCP 6 homolog
Target Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
Target Subcellular Location
Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium.
Target Tissue Specificity
Broadly expressed in the immune system and can be detected in T and B-cells.
Target Synonyms
DEF-6; Def6; DEFI6_HUMAN; Differentially expressed in FDCP 6 homolog; Differentially expressed in FDCP 6 homologue mouse; IBP; IRF4-binding protein; Swap70 like adapter of T cells
Target Background
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).
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