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The antibody against MTMR8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against MTMR8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-07049A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MTMR8 |
| Target Synonyms | MTMR8 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-29, SKOV3, U-87MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | HVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQ | Uniprot ID | Q96EF0 |
Uniprot Id
Q96EF0
Target Species
Human
Target Name
MTMR8
Target Full Name
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8
Target Function
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. In complex with MTMR9, negatively regulates autophagy.
Target Subcellular Location
Nucleus envelope.
Target Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Target Synonyms
C8orf9; DKFZP434K171; FLJ20126; LIP STYX; MTMR8; MTMR8_HUMAN; MTMR9; Myotubularin related protein 8; Myotubularin related protein 9; Myotubularin-related protein 8
Target Background
This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases.
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