Rabbit anti-Human CBX7 Polyclonal Antibody

The antibody against CBX7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 162-251 of human CBX7(NP_783640.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB.

ADA-08358A

Number

Cat.No	ADA-08358A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CBX7
Target Synonyms	CBX7	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Jurkat, U-251 MG	Application	WB

Cat.No

ADA-08358A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CBX7

Target Synonyms

CBX7

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Jurkat, U-251 MG

Application

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 162-251 of human CBX7(NP_783640.1).	Target Species	Human
Immunogen Sequence	NLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF	Uniprot ID	O95931

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 162-251 of human CBX7(NP_783640.1).

Target Species

Human

Immunogen Sequence

NLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF

Uniprot ID

O95931

Background Information

Uniprot Id

O95931
Target Species

Human
Target Name

CBX7
Target Full Name

Chromobox protein homolog 7
Target Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Target Subcellular Location

Nucleus.
Target Research Area

Transcription
Target Synonyms

CBX7; Chromobox protein homolog 7
Target Background

This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells.

Rabbit anti-Human CBX7 Polyclonal Antibody

Specifications

Immunogen Information

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