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The antibody against THOP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against THOP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-08945A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | THOP1 |
| Target Synonyms | TOP; MP78; EP24.15; MEPD_HUMAN; THOP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse lung, Mouse skeletal muscle, Rat kidney, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P52888 | Immunogen Sequence |
Uniprot Id
P52888
Target Species
Human
Target Name
THOP1
Target Full Name
Thimet oligopeptidase
Target Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Peptidase M3 family
Target Synonyms
EC 3.4.24.15; Endopeptidase 24.15; EP24.15 ; MEPD_HUMAN; MP78; Thimet oligopeptidase 1; Thimet oligopeptidase; Thop1; THOP1_HUMAN; TOP
Target Background
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides.
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