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The antibody against FSTL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FSTL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09025A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FSTL3 |
| Target Synonyms | FLRG; FSRP; FSTL3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, DU145, MCF7, Mouse lung, Rat lung, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O95633 | Immunogen Sequence |
Uniprot Id
O95633
Target Species
Human
Target Name
FSTL3
Target Full Name
Follistatin-related protein 3
Target Function
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10
Target Involvement
A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
Target Subcellular Location
[Isoform 1]: Secreted.; [Isoform 2]: Nucleus.
Target Tissue Specificity
Expressed in a wide range of tissues.
Target Synonyms
FLRG; follistatin-like 3; follistatin-like 3 glycoprotein ; Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3; FSRP; Fstl3; FSTL3_HUMAN
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