Rabbit anti-Human SLIRP Polyclonal Antibody

The antibody against SLIRP was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLIRP (NP_112487.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-10085A

Number

Cat.No	ADA-10085A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	SLIRP
Target Synonyms	DC50; PD04872; C14orf156; SLIRP	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, NIH/3T3, DU145, Mouse brain	Application	ELISA, WB, IHC-P

Cat.No

ADA-10085A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

SLIRP

Target Synonyms

DC50; PD04872; C14orf156; SLIRP

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, NIH/3T3, DU145, Mouse brain

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLIRP (NP_112487.1).	Target Species	Human
Immunogen Sequence	MAASAARGAAALRRSINQPVAFVRRIPWTAASSQLKEHFAQFGHVRRCILPFDKETGFHRGLGWVQFSSEEGLRNALQQENHIIDGVKVQVHTRRPKLPQ	Uniprot ID	Q9GZT3

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLIRP (NP_112487.1).

Target Species

Human

Immunogen Sequence

MAASAARGAAALRRSINQPVAFVRRIPWTAASSQLKEHFAQFGHVRRCILPFDKETGFHRGLGWVQFSSEEGLRNALQQENHIIDGVKVQVHTRRPKLPQ

Uniprot ID

Q9GZT3

Background Information

Uniprot Id

Q9GZT3
Target Species

Human
Target Name

SLIRP
Target Full Name

SRA stem-loop-interacting RNA-binding protein, mitochondrial
Target Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.
Target Subcellular Location

Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
Target Tissue Specificity

Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.
Target Synonyms

SLIRP; C14orf156; DC23; DC50; PD04872; SRA stem-loop-interacting RNA-binding protein; mitochondrial
Target Background

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).

Rabbit anti-Human SLIRP Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human SLIRP Polyclonal Antibody Now

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