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The antibody against ALG2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 197-416 of human ALG2 (NP_149078.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ALG2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 197-416 of human ALG2 (NP_149078.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Immunofluorescence analysis of U2OS cells using ALG2 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
| Cat.No | ADA-10772A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ALG2 |
| Target Synonyms | CDG1I; CDGIi; CMS14; NET38; CMSTA3; hALPG2; ALG2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 197-416 of human ALG2 (NP_149078.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H553 | Immunogen Sequence |
Uniprot Id
Q9H553
Target Species
Human
Target Name
ALG2
Target Full Name
Alpha-1,3/1,6-mannosyltransferase ALG2
Target Function
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
Target Involvement
Congenital disorder of glycosylation 1I (CDG1I); Myasthenic syndrome, congenital, 14 (CMS14)
Target Subcellular Location
Membrane; Single-pass membrane protein.
Target Protein Families
Glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily
Target Synonyms
ALG2; UNQ666/PRO1298; Alpha-1,3/1,6-mannosyltransferase ALG2; Asparagine-linked glycosylation protein 2 homolog; GDP-Man:Man(1GlcNAc(2-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(1GlcNAc(2-PP-dolichol mannosyltransferase; GDP-Man:Man(2GlcNAc(2-PP-Dol alpha-1,6-mannosyltransferase
Target Background
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1, 3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants.
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