Rabbit anti-Human FCGR3A Polyclonal Antibody

The antibody against FCGR3A was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_000560.7) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11290A

Number

Cat.No	ADA-11290A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	FCGR3A
Target Synonyms	CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA; FCGR3A	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	K-562, Mouse liver, Mouse testis, Rat lung	Application	ELISA, WB

Cat.No

ADA-11290A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

FCGR3A

Target Synonyms

CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA; FCGR3A

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

K-562, Mouse liver, Mouse testis, Rat lung

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_000560.7).	Target Species	Human
Immunogen Sequence	YFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKD	Uniprot ID	P08637

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human FCGR3A (NP_000560.7).

Target Species

Human

Immunogen Sequence

YFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKD

Uniprot ID

P08637

Background Information

Uniprot Id

P08637
Target Species

Human
Target Name

FCGR3A
Target Full Name

Low affinity immunoglobulin gamma Fc region receptor III-A
Target Function

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Target Involvement

Immunodeficiency 20 (IMD20)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor.
Target Tissue Specificity

Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
Target Research Area

Immunology
Target Synonyms

FCGR3A; CD16A; FCG3; FCGR3; IGFR3; Low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD antigen CD16a
Target Background

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human FCGR3A Polyclonal Antibody

Specifications

Immunogen Information

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