Rabbit anti-Human AKAP3 Polyclonal Antibody

Uniprot Id

O75969

Target Species

Human

Target Name

AKAP3

Target Full Name

A-kinase anchor protein 3

Target Function

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

Target Subcellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

Target Protein Families

AKAP110 family

Target Tissue Specificity

Testis specific; only expressed in spermatids.

Target Synonyms

A kinase (PRKA) anchor protein 3; A-kinase anchor protein 110 kDa; A-kinase anchor protein 3; AKAP 110; AKAP-3; AKAP110; Akap3; AKAP3_HUMAN; Cancer/testis antigen 82; CT82; Fibrous sheath protein of 95 kDa; Fibrousheathin 1; Fibrousheathin I; Fibrousheathin-1; FSP95; PRKA3; protein kinase A binding protein AKAP 110; Protein kinase A-anchoring protein 3; SOB 1; SOB1; Sperm oocyte binding protein 1 ; Sperm oocyte-binding protein

Target Background

This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction.