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The antibody against BAG5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 198-447 of human BAG5 (NP_004864.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against BAG5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 198-447 of human BAG5 (NP_004864.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-03669A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BAG5 |
| Target Synonyms | BAG-5; CMD2F; BAG5 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, MCF7, Mouse lung, Mouse testis, Rat lung, SH-SY5Y | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 198-447 of human BAG5 (NP_004864.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UL15 | Immunogen Sequence |
Uniprot Id
Q9UL15
Target Species
Human
Target Name
BAG5
Target Full Name
BAG family molecular chaperone regulator 5
Target Function
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Target Research Area
Cancer
Target Synonyms
BAG family molecular chaperone regulator 5; BAG-5; BAG5; BAG5_HUMAN; Bcl 2 associated athanogene 5; Bcl-2-associated athanogene 5; BCL2 associated athanogene 5; KIAA0873
Target Background
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.
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