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The antibody against BLMH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BLMH (NP_000377.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against BLMH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BLMH (NP_000377.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09468A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BLMH |
| Target Synonyms | BH; BMH; BLMH | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | NCI-H460, Rat thymus | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BLMH (NP_000377.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13867 | Immunogen Sequence |
Uniprot Id
Q13867
Target Species
Human
Target Name
BLMH
Target Full Name
Bleomycin hydrolase
Target Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Target Subcellular Location
Cytoplasm. Cytoplasmic granule.
Target Protein Families
Peptidase C1 family
Target Synonyms
BH; Bleomycin hydrolase; BLM hydrolase; BLMH; BLMH_HUMAN; BMH; EC 3.4.22.40
Target Background
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
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