Rabbit anti-Human BRWD1 Polyclonal Antibody

Uniprot Id

Q9NSI6

Target Species

Human

Target Name

BRWD1

Target Full Name

Bromodomain and WD repeat-containing protein 1

Target Function

May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

Bromodomain and WD repeat domain containing protein 1; Bromodomain and WD repeat-containing protein 1; Brwd1; BRWD1_HUMAN; C21orf107; cAMP response element binding and beta tranducin family; FLJ11315; N143; Transcriptional unit N143; WD repeat protein; WD repeat-containing protein 9; WDR9

Target Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.