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The antibody against BSND was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 54-320 of human BSND (NP_476517.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BSND was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 54-320 of human BSND (NP_476517.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01966A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BSND |
| Target Synonyms | BART; DFNB73; BSND | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Rat intestine, Rat kidney, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 54-320 of human BSND (NP_476517.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WZ55 | Immunogen Sequence |
Uniprot Id
Q8WZ55
Target Species
Human
Target Name
BSND
Target Full Name
Barttin
Target Function
Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
Target Involvement
Bartter syndrome 4A, neonatal, with sensorineural deafness (BARTS4A)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasm.
Target Tissue Specificity
Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear.
Target Synonyms
BART ; Bartter syndrome infantile with sensorineural deafness; Bartter syndrome; infantile; with sensorineural deafness (Barttin); Barttin; Bsnd; BSND_HUMAN; deafness; autosomal recessive 73; DFNB 73; DFNB73
Target Background
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness.
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