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The antibody against C8B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 55-350 of human C8B (NP_000057.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against C8B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 55-350 of human C8B (NP_000057.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01517A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | C8B |
| Target Synonyms | C82; C8B | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HepG2, Jurkat, Mouse liver, Raji, Rat liver, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 55-350 of human C8B (NP_000057.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P07358 | Immunogen Sequence |
Uniprot Id
P07358
Target Species
Human
Target Name
C8B
Target Full Name
Complement component C8 beta chain
Target Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Target Involvement
Complement component 8 deficiency, 2 (C8D2)
Target Subcellular Location
Secreted.
Target Protein Families
Complement C6/C7/C8/C9 family
Target Research Area
Cardiovascular
Target Synonyms
C8b; CO8B_HUMAN; Complement component 8 beta polypeptide; Complement component 8 subunit beta; Complement component C8 beta chain
Target Background
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants.
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