Rabbit anti-Human CACNA2D3 Polyclonal Antibody

The antibody against CACNA2D3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human CACNA2D3 (NP_060868.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09038A

Number

Cat.No	ADA-09038A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CACNA2D3
Target Synonyms	HSA272268; CACNA2D3	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Rat brain, HepG2, Mouse brain, U-87MG	Application	ELISA, WB

Cat.No

ADA-09038A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CACNA2D3

Target Synonyms

HSA272268; CACNA2D3

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Rat brain, HepG2, Mouse brain, U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human CACNA2D3 (NP_060868.2).	Target Species	Human
Immunogen Sequence	LYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKC	Uniprot ID	Q8IZS8

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human CACNA2D3 (NP_060868.2).

Target Species

Human

Immunogen Sequence

LYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKC

Uniprot ID

Q8IZS8

Background Information

Uniprot Id

Q8IZS8
Target Species

Human
Target Name

CACNA2D3
Target Full Name

Voltage-dependent calcium channel subunit alpha-2/delta-3
Target Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Protein Families

Calcium channel subunit alpha-2/delta family
Target Tissue Specificity

Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed.
Target Synonyms

CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3; Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3]
Target Background

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Rabbit anti-Human CACNA2D3 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human CACNA2D3 Polyclonal Antibody Now

Related Products