Rabbit anti-Human CD1B Polyclonal Antibody

Uniprot Id

P29016

Target Species

Human

Target Name

CD1B

Target Full Name

T-cell surface glycoprotein CD1b

Target Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Target Synonyms

CD1B; T-cell surface glycoprotein CD1b; CD antigen CD1b

Target Background

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.