Rabbit anti-Human CDT1 Polyclonal Antibody

The antibody against CDT1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CDT1 (NP_112190.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-08723A

Number

Cat.No	ADA-08723A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CDT1
Target Synonyms	DUP; RIS2; CDT1	Form	Liquid
Species Reactivity	Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Application	ELISA, WB

Cat.No

ADA-08723A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CDT1

Target Synonyms

DUP; RIS2; CDT1

Form

Liquid

Species Reactivity

Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CDT1 (NP_112190.2).	Target Species	Human
Immunogen Sequence	PATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL	Uniprot ID	Q9H211

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CDT1 (NP_112190.2).

Target Species

Human

Immunogen Sequence

PATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL

Uniprot ID

Q9H211

Background Information

Uniprot Id

Q9H211
Target Species

Human
Target Name

CDT1
Target Full Name

DNA replication factor Cdt1
Target Function

Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene.
Target Involvement

Meier-Gorlin syndrome 4 (MGORS4)
Target Subcellular Location

Nucleus. Chromosome, centromere, kinetochore.
Target Protein Families

Cdt1 family
Target Synonyms

CDT 1; cdt1; CDT1_HUMAN; Chromatin licensing and DNA replication factor 1; DNA replication factor; DNA replication factor Cdt1; Double parked; Double parked Drosophila homolog of; Double parked homolog; DUP; Retroviral integration site 1; Retroviral integration site 2; Retroviral integration site1; Retroviral integration site2; RIS 2; RIS2
Target Background

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein.

Rabbit anti-Human CDT1 Polyclonal Antibody

Specifications

Immunogen Information

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