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The antibody against Cleaved IL-18 (Tyr37) was raised in Rabbit using a synthetic peptide corresponding to residues surrounding Tyr37 of human IL18 (NP_001553.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB.
The antibody against Cleaved IL-18 (Tyr37) was raised in Rabbit using a synthetic peptide corresponding to residues surrounding Tyr37 of human IL18 (NP_001553.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB.
| Cat.No | ADA-15632A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Cleaved IL-18 (Tyr37) |
| Target Synonyms | mature IL-18; Cleaved IL-18 (Tyr37) | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | GSDMD knockout (KO) HeLa cells transfected with LPS, Recombinant Human IL-18 Protein | Application | WB |
| Immunogen Description | A synthetic peptide corresponding to residues surrounding Tyr37 of human IL18 (NP_001553.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14116 |
Uniprot Id
Q14116
Target Species
Human
Target Name
IL18
Target Full Name
Interleukin-18
Target Function
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable).
Target Subcellular Location
Cytoplasm. Secreted.
Target Protein Families
IL-1 family
Target Research Area
Immunology
Target Synonyms
Iboctadekin; IFN gamma inducing factor; IFN-gamma-inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL-1 gamma; IL-18; IL1 gamma; IL18; IL18 protein; IL18_HUMAN; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interferon gamma-inducing factor; Interleukin 1 gamma; Interleukin 18 (interferon-gamma-inducing factor); Interleukin 18; Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
Target Background
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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