Rabbit anti-Human CYP2F1 Polyclonal Antibody

The antibody against CYP2F1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-290 of human CYP2F1 (NP_000765.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-02436A

Number

Cat.No	ADA-02436A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CYP2F1
Target Synonyms	C2F1; CYP2F; CYPIIF1; CYP2F1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, BT-474, Mouse liver, Mouse lung, Rat liver, SW620	Application	ELISA, WB, IHC-P

Cat.No

ADA-02436A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CYP2F1

Target Synonyms

C2F1; CYP2F; CYPIIF1; CYP2F1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, BT-474, Mouse liver, Mouse lung, Rat liver, SW620

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 100-290 of human CYP2F1 (NP_000765.2).	Target Species	Human
Immunogen Sequence	DYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLM	Uniprot ID	P24903

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 100-290 of human CYP2F1 (NP_000765.2).

Target Species

Human

Immunogen Sequence

DYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLM

Uniprot ID

P24903

Background Information

Uniprot Id

P24903
Target Species

Human
Target Name

CYP2F1
Target Full Name

Cytochrome P450 2F1
Target Function

May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families

Cytochrome P450 family
Target Tissue Specificity

Expressed in lung. Rarely detected in liver and placenta.
Target Synonyms

CYP2F1Cytochrome P450 2F1; EC 1.14.14.1; CYPIIF1
Target Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Rabbit anti-Human CYP2F1 Polyclonal Antibody

Specifications

Immunogen Information

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