Rabbit anti-Human DDX3Y Polyclonal Antibody

Uniprot Id

O15523

Target Species

Human

Target Name

DDX3Y

Target Full Name

ATP-dependent RNA helicase DDX3Y

Target Function

Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway.

Target Involvement

DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.

Target Protein Families

DEAD box helicase family, DDX3/DED1 subfamily

Target Tissue Specificity

Widely expressed at the mRNA level, with highest levels in testis. Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes.

Target Synonyms

ATP dependent RNA helicase DDX3Y; ATP-dependent RNA helicase DDX3Y; DBY ; DDX3Y; DDX3Y_HUMAN; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked ; DEAD box protein 3 Y chromosomal; DEAD box protein 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome; Y-chromosomal

Target Background

The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.