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The antibody against DHRS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human DHRS4 (NP_066284.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DHRS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human DHRS4 (NP_066284.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01385A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DHRS4 |
| Target Synonyms | CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL; DHRS4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, A-549, LO2, MCF7, Mouse liver, Mouse lung, Mouse small intestine, Rat liver, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human DHRS4 (NP_066284.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BTZ2 | Immunogen Sequence |
Uniprot Id
Q9BTZ2
Target Species
Human
Target Name
DHRS4
Target Full Name
Dehydrogenase/reductase SDR family member 4
Target Function
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
Target Subcellular Location
Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.; [Isoform 7]: Nucleus.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity
Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
Target Synonyms
AI043103; AI790593; Carbonyl reductase; CR; D14Ucla2; Dehydrogenase/reductase SDR family member 4; Dhrs4; DHRS4_HUMAN; humNRDR; mouNRDR; NADPH dependent carbonyl reductase/NADP retinol dehydrogenase; NADPH dependent retinol dehydrogenase/reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; NRDR; Peroxisomal short chain alcohol dehydrogenase; Peroxisomal short-chain alcohol dehydrogenase; PHCR; PRO1800; PSCD; RRD; SCAD-SRL; SCADSRL ; Short chain dehydrogenase/reductase family member 4; Short-chain dehydrogenase/reductase family member 4; UNQ851
Target Background
Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including cellular ketone metabolic process; positive regulation of reactive oxygen species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane.
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