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The antibody against DTX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DTX2 (NP_065943.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against DTX2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DTX2 (NP_065943.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-08604A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DTX2 |
| Target Synonyms | RNF58; DTX2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DTX2 (NP_065943.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q86UW9 | Immunogen Sequence |
Uniprot Id
Q86UW9
Target Species
Human
Target Name
DTX2
Target Full Name
Probable E3 ubiquitin-protein ligase DTX2
Target Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Deltex family
Target Synonyms
Deltex 2; deltex homolog 2 (Drosophila); deltex; Drosophila; homolog of; 2; Deltex2; DTX2; DTX2_HUMAN; hDTX2; Highly similar to hPMSR6 [H.sapiens]; KIAA1528; Probable E3 ubiquitin-protein ligase DTX2; Protein deltex 2; Protein deltex-2; RING finger protein 58; RNF58; Zinc ion binding protein
Target Background
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).
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