Rabbit anti-Human DYNC2LI1 Polyclonal Antibody

Uniprot Id

Q8TCX1

Target Species

Human

Target Name

DYNC2LI1

Target Full Name

Cytoplasmic dynein 2 light intermediate chain 1

Target Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length.

Target Involvement

Short-rib thoracic dysplasia 15 with polydactyly (SRTD15)

Target Subcellular Location

Golgi apparatus. Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

Dynein light intermediate chain family

Target Tissue Specificity

Expressed in bone, brain, kidney, and cartilage. Lower expression in heart, liver, lung, placenta and thymus.

Target Research Area

Signal Transduction

Target Synonyms

CGI-60; Cytoplasmic dynein 2 light intermediate chain 1; D2LIC; DC2L1_HUMAN; DYNC2LI1; Dynein 2 light intermediate chain; Dynein, cytoplasmic 2, light intermediate chain 1; LIC3

Target Background

This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms.