Rabbit anti-Human EED Polyclonal Antibody

The antibody against EED was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-400 of human EED (NP_694536.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.

ADA-11203A

Number

Cat.No	ADA-11203A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	EED
Target Synonyms	HEED; COGIS; WAIT1; EED	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse brain	Application	ELISA, WB, IF/ICC, IP

Cat.No

ADA-11203A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

EED

Target Synonyms

HEED; COGIS; WAIT1; EED

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse brain

Application

ELISA, WB, IF/ICC, IP

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-400 of human EED (NP_694536.1).	Target Species	Human
Uniprot ID	O75530	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-400 of human EED (NP_694536.1).

Target Species

Human

Uniprot ID

O75530

Immunogen Sequence

Background Information

Uniprot Id

O75530
Target Species

Human
Target Name

EED
Target Full Name

Polycomb protein EED
Target Function

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Target Involvement

Cohen-Gibson syndrome (COGIS)
Target Subcellular Location

Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Target Protein Families

WD repeat ESC family
Target Tissue Specificity

Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
Target Synonyms

eed; EED protein; EED; mouse; homolog of; EED_HUMAN; Embryonic ectoderm development; Embryonic ectoderm development isoform a; Embryonic ECTODERM development protein homolog; Embryonic ectoderm development protein; mouse; homolog of; hEED; OTTHUMP00000235483; OTTHUMP00000235484; OTTHUMP00000235485; Polycomb protein eed; WAIT 1; WAIT-1; WAIT1; WD protein associating with integrin cytoplasmic tails 1
Target Background

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Rabbit anti-Human EED Polyclonal Antibody

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Immunogen Information

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