Rabbit anti-Human FCN1 Polyclonal Antibody

Uniprot Id

O00602

Target Species

Human

Target Name

FCN1

Target Full Name

Ficolin-1

Target Function

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Target Subcellular Location

Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Found on the monocyte and granulocyte surface (PubMed:20400674).

Target Protein Families

Ficolin lectin family

Target Tissue Specificity

Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.

Target Synonyms

Collagen/fibrinogen domain containing protein 1 ; Collagen/fibrinogen domain-containing protein 1; Fcn1; FCN1_HUMAN; FCNM ; ficolin (collagen/fibrinogen domain containing) 1; Ficolin 1; Ficolin A; Ficolin alpha; Ficolin-1; Ficolin-A; Ficolin-alpha; M ficolin; M-ficolin

Target Background

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.