Rabbit anti-Human FPGS Monoclonal Antibody

The antibody against FPGS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS (Q05932) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-13299A

Number

Cat.No	ADA-13299A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	FPGS
Form	Liquid	Species Reactivity	Human, Rat
Isotype	IgG	Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.
Purification Method	Affinity purification	Positive Samples	Jurkat, MCF7, Molt-4, PC-3, Rat lung
Application	ELISA, WB

Cat.No

ADA-13299A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

FPGS

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Jurkat, MCF7, Molt-4, PC-3, Rat lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS (Q05932).	Target Species	Human
Immunogen Sequence	NADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ	Uniprot ID	Q05932

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS (Q05932).

Target Species

Human

Immunogen Sequence

NADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ

Uniprot ID

Q05932

Background Information

Uniprot Id

Q05932
Target Species

Human
Target Name

FPGS
Target Full Name

Folylpolyglutamate synthase, mitochondrial
Target Function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Target Subcellular Location

[Isoform 1]: Mitochondrion inner membrane. Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
Target Protein Families

Folylpolyglutamate synthase family
Target Background

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms.

Rabbit anti-Human FPGS Monoclonal Antibody

Specifications

Immunogen Information

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