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The antibody against GAMT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-236 of human GAMT (NP_000147.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against GAMT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-236 of human GAMT (NP_000147.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-09459A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAMT |
| Target Synonyms | PIG2; CCDS2; TP53I2; HEL-S-20; GAMT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, 293T, HepG2, Jurkat, Mouse liver, Rat liver | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-236 of human GAMT (NP_000147.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14353 | Immunogen Sequence |
Uniprot Id
Q14353
Target Species
Human
Target Name
GAMT
Target Full Name
Guanidinoacetate N-methyltransferase
Target Function
Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.
Target Involvement
Cerebral creatine deficiency syndrome 2 (CCDS2)
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, RMT2 methyltransferase family
Target Tissue Specificity
Expressed in liver.
Target Synonyms
CCDS2; Epididymis secretory protein Li 20; GAMT; GAMT_HUMAN; Guanidinoacetate N methyltransferase; Guanidinoacetate N-methyltransferase; HEL-S-20; PIG2; TP53I2
Target Background
The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13.
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