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The antibody against GNPTAB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 42-350 of human GNPTAB (NP_077288.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GNPTAB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 42-350 of human GNPTAB (NP_077288.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10036A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNPTAB |
| Target Synonyms | ICD; GNPTA; GNPTAB | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, LO2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 42-350 of human GNPTAB (NP_077288.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q3T906 | Immunogen Sequence |
Uniprot Id
Q3T906
Target Species
Human
Target Name
GNPTAB
Target Full Name
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Target Function
Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.
Target Involvement
Mucolipidosis type II (MLII); Mucolipidosis type III complementation group A (MLIIIA)
Target Subcellular Location
[N-acetylglucosamine-1-phosphotransferase subunit alpha]: Golgi apparatus membrane; Single-pass type I membrane protein.; [N-acetylglucosamine-1-phosphotransferase subunit beta]: Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Stealth family
Target Tissue Specificity
Expressed in the heart, whole brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Target Synonyms
GNPTAB; GNPTA; KIAA1208; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; GlcNAc-1-phosphotransferase subunits alpha/beta; Stealth protein GNPTAB; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
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