Rabbit anti-Human GRIN2C Polyclonal Antibody

Uniprot Id

Q14957

Target Species

Human

Target Name

GRIN2C

Target Full Name

Glutamate receptor ionotropic, NMDA 2C

Target Function

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Target Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, NR2C/GRIN2C subfamily

Target Tissue Specificity

Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.

Target Synonyms

GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C; Glutamate receptor ionotropic, NMDA 2C; Glutamate receptor, ionotropic, N methyl D aspartate 2C; Grin2c; N Methly D Aspartate Receptor Channel Subunit Epsilon 3; N Methyl D Aspartate Receptor Subtype 2C; N methyl D aspartate receptor subunit 2C; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NMDE3_HUMAN; NR2C; OTTHUMP00000041930

Target Background

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants.