Rabbit anti-Human GRK6 Polyclonal Antibody

The antibody against GRK6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 268-465 of human GRK6 (NP_001004106.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03061A

Number

Cat.No	ADA-03061A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	GRK6
Target Synonyms	GPRK6; GRK6	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, Jurkat, MCF7	Application	ELISA, WB

Cat.No

ADA-03061A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

GRK6

Target Synonyms

GPRK6; GRK6

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, Jurkat, MCF7

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 268-465 of human GRK6 (NP_001004106.1).	Target Species	Human
Immunogen Sequence	GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPF	Uniprot ID	P43250

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 268-465 of human GRK6 (NP_001004106.1).

Target Species

Human

Immunogen Sequence

GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPF

Uniprot ID

P43250

Background Information

Uniprot Id

P43250
Target Species

Human
Target Name

GRK6
Target Full Name

G protein-coupled receptor kinase 6
Target Function

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Target Subcellular Location

Membrane; Lipid-anchor.
Target Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
Target Tissue Specificity

Widely expressed.
Target Synonyms

FLJ32135; G protein coupled receptor kinase 6; G protein coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; Gprk6; Grk6; GRK6_HUMAN
Target Background

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.

Rabbit anti-Human GRK6 Polyclonal Antibody

Specifications

Immunogen Information

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