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The antibody against HEY2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human HEY2 (NP_036391.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HEY2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human HEY2 (NP_036391.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05248A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HEY2 |
| Target Synonyms | GRL; CHF1; HRT2; HERP1; HESR2; bHLHb32; GRIDLOCK; HEY2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HepG2, Rat lung, Rat testis, SH-SY5Y | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HEY2 (NP_036391.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | TIDVGSENNYSGQSTS | Uniprot ID | Q9UBP5 |
Uniprot Id
Q9UBP5
Target Species
Human
Target Name
HEY2
Target Full Name
Hairy/enhancer-of-split related with YRPW motif protein 2
Target Function
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Target Subcellular Location
Nucleus.
Target Protein Families
HEY family
Target Synonyms
bHLHb32; Cardiovascular helix loop helix factor 1; Cardiovascular helix-loop-helix factor 1; CHF1; Class B basic helix-loop-helix protein 32; GRIDLOCK; GRL; Hairy and enhancer of split related 2; Hairy and enhancer of split-related protein 2; Hairy related transcription factor 2; Hairy-related transcription factor 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; HERP; HERP1; HES related repressor protein 1; HES-related repressor protein 2; HESR-2; HESR2; hey2; HEY2_HUMAN; hHRT2; HRT-2; HRT2 ; MGC10720; Protein gridlock homolog
Target Background
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
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