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The antibody against HIP1R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_003950.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against HIP1R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_003950.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02133A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HIP1R |
| Target Synonyms | HIP3; HIP12; ILWEQ; HIP1R | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, 293T, Mouse brain, Mouse liver, Mouse spleen, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_003950.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O75146 | Immunogen Sequence |
Uniprot Id
O75146
Target Species
Human
Target Name
HIP1R
Target Full Name
Huntingtin-interacting protein 1-related protein
Target Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Target Subcellular Location
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Target Protein Families
SLA2 family
Target Tissue Specificity
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
Target Synonyms
FLJ14000; FLJ27022; HIP-12; Hip1 related ; HIP1-related protein; HIP12; HIP1R; HIP1R_HUMAN; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; ILWEQ; KIAA0655; MGC47513
Target Background
Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3, 4-bisphosphate binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; protein stabilization; and regulation of organelle organization. Located in clathrin-coated vesicle; cytosol; and ruffle membrane.
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