Rabbit anti-Human IGFBP3 Polyclonal Antibody

Uniprot Id

P17936

Target Species

Human

Target Name

IGFBP3

Target Full Name

Insulin-like growth factor-binding protein 3

Target Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis.

Target Subcellular Location

Secreted.

Target Tissue Specificity

Expressed by most tissues. Present in plasma.

Target Synonyms

IBP3; BP-53; IGFBP3

Target Background

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.