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The antibody against IGFBP6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IGFBP6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09006A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IGFBP6 |
| Target Synonyms | IBP6; IGFBP6 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, SW480 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P24592 | Immunogen Sequence |
Uniprot Id
P24592
Target Species
Human
Target Name
IGFBP6
Target Full Name
Insulin-like growth factor-binding protein 6
Target Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
Target Subcellular Location
Secreted.
Target Synonyms
IBP 6; IBP-6; IBP6; IBP6_HUMAN; IGF binding protein 6; IGF-binding protein 6; IGFBP 6; IGFBP-6; IGFBP6; Insulin like growth factor binding protein 6; Insulin-like growth factor-binding protein 6
Target Background
Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy.
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