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The antibody against IL17RB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_061195.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IL17RB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_061195.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06471A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL17RB |
| Target Synonyms | CRL4; EVI27; IL17BR; IL17RH1; IL17RB | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-549, B-cell, HepG2, Mouse liver, Rat liver, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 18-292 of human IL17RB (NP_061195.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NRM6 | Immunogen Sequence |
Uniprot Id
Q9NRM6
Target Species
Human
Target Name
IL17RB
Target Full Name
Interleukin-17 receptor B
Target Function
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Target Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Target Tissue Specificity
Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.
Target Synonyms
IL17RB; CRL4; EVI27; IL17BR; UNQ2501/PRO19612; Interleukin-17 receptor B; IL-17 receptor B; IL-17RB; Cytokine receptor-like 4; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; Interleukin-17B receptor; IL-17B receptor
Target Background
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
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