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The antibody against IQSEC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IQSEC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01669A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IQSEC1 |
| Target Synonyms | BRAG2; GEP100; IDDSSBA; ARFGEP100; ARF-GEP100; IQSEC1 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_055684.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6DN90 | Immunogen Sequence |
Uniprot Id
Q6DN90
Target Species
Human
Target Name
IQSEC1
Target Full Name
IQ motif and SEC7 domain-containing protein 1
Target Function
Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development. In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors.
Target Subcellular Location
Cytoplasm. Nucleus. Cell junction, synapse, postsynaptic density. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=At steady state, may be preferentially cytosolic.
Target Protein Families
BRAG family
Target Tissue Specificity
Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
Target Synonyms
IQSEC1; ARFGEP100; BRAG2; KIAA0763; IQ motif and SEC7 domain-containing protein 1; ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; Brefeldin-resistant Arf-GEF 2 protein; BRAG2
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