Rabbit anti-Human IRF6 Monoclonal Antibody

The antibody against IRF6 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6 (O14896) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.

ADA-16187A

Number

Cat.No	ADA-16187A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	IRF6
Target Synonyms	LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1; IRF6	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, 293T, A-549, HepG2, Mouse lung, Rat liver, Rat lung	Application	ELISA, WB, IF/ICC, IP

Cat.No

ADA-16187A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

IRF6

Target Synonyms

LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1; IRF6

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, 293T, A-549, HepG2, Mouse lung, Rat liver, Rat lung

Application

ELISA, WB, IF/ICC, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6 (O14896).	Target Species	Human
Immunogen Sequence	PFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ	Uniprot ID	O14896

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6 (O14896).

Target Species

Human

Immunogen Sequence

PFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ

Uniprot ID

O14896

Background Information

Uniprot Id

O14896
Target Species

Human
Target Name

IRF6
Target Full Name

Interferon regulatory factor 6
Target Function

Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.
Target Involvement

Van der Woude syndrome 1 (VWS1); Popliteal pterygium syndrome (PPS); Non-syndromic orofacial cleft 6 (OFC6)
Target Subcellular Location

Nucleus. Cytoplasm.
Target Protein Families

IRF family
Target Tissue Specificity

Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Target Synonyms

Interferon regulatory factor 6; IRF 6; IRF-6; IRF6; IRF6_HUMAN; LPS; OFC 6; OFC6; OTTHUMP00000034677; OTTHUMP00000034678; PIT; PPS; PPS1; VWS; VWS1
Target Background

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Rabbit anti-Human IRF6 Monoclonal Antibody

Specifications

Immunogen Information

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