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The antibody against IRS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1238-1338 of human IRS2 (NP_003740.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against IRS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1238-1338 of human IRS2 (NP_003740.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-09163A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IRS2 |
| Target Synonyms | IRS-2; IRS2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | SH-SY5Y, U2OS | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1238-1338 of human IRS2 (NP_003740.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | PMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE | Uniprot ID | Q9Y4H2 |
Uniprot Id
Q9Y4H2
Target Species
Human
Target Name
IRS2
Target Full Name
Insulin receptor substrate 2
Target Function
May mediate the control of various cellular processes by insulin.
Target Subcellular Location
Cytoplasm, cytosol.
Target Synonyms
Insulin receptor substrate 2; IRS 2; IRS-2; Irs2; IRS2_HUMAN
Target Background
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
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