Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against IWS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 570-819 of human IWS1 (NP_060439.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IWS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 570-819 of human IWS1 (NP_060439.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02543A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IWS1 |
| Target Synonyms | IWS1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse lung, Mouse ovary, Mouse spleen, Mouse testis, NCI-H460 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 570-819 of human IWS1 (NP_060439.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96ST2 | Immunogen Sequence |
Uniprot Id
Q96ST2
Target Species
Human
Target Name
IWS1
Target Full Name
Protein IWS1 homolog
Target Function
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Target Subcellular Location
Nucleus.
Target Protein Families
IWS1 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
DKFZp761G0123; FLJ10006; FLJ14655; FLJ32319; Interacts with Spt6; iws1; IWS1 homolog; IWS1-like protein; IWS1_HUMAN; IWS1L; MGC126375; MGC126376; OTTHUMP00000162262; Protein IWS1 homolog
Target Background
Involved in regulation of histone modification; regulation of mRNA export from nucleus; and regulation of mRNA processing. Located in nucleoplasm.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
