Rabbit anti-Human KCNMB1 Polyclonal Antibody

Uniprot Id

Q16558

Target Species

Human

Target Name

KCNMB1

Target Full Name

Calcium-activated potassium channel subunit beta-1

Target Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

KCNMB (TC 8.A.14.1) family, KCNMB1 subfamily

Target Tissue Specificity

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.

Target Synonyms

BK channel beta subunit; BK channel subunit beta 1; BK channel subunit beta-1; BKbeta; BKbeta1; Calcium activated potassium channel subfamily M subunit beta 1; Calcium activated potassium channel subunit beta 1; Calcium activated potassium channel subunit beta; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel subunit beta-1; Charybdotoxin receptor subunit beta 1; Charybdotoxin receptor subunit beta-1; Hbeta1; hslo beta; K(VCA)beta 1; K(VCA)beta; K(VCA)beta-1; KCMB1_HUMAN; KCNMB 1; Kcnmb1; Large conductance Ca2+ activated K+ channel beta 1 subunit; Maxi K channel beta subunit; Maxi K channel subunit beta 1; Maxi K channel subunit beta-1; Potassium large conductance calcium activated channel subfamily M beta member 1; Slo beta 1; SLO beta; Slo-beta; Slo-beta-1; subfamily M subunit beta-1

Target Background

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.