Rabbit anti-Human KDM4B/JMJD2B Monoclonal Antibody

The antibody against KDM4B/JMJD2B was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 50-150 of human KDM4B/JMJD2B (O94953) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ChIP, ELISA.

ADA-16895A

Number

Cat.No	ADA-16895A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	KDM4B/JMJD2B
Target Synonyms	MRD65; JMJD2B; TDRD14B; KDM4B/JMJD2B	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HCT 116, Mouse brain	Application	ELISA, WB, ChIP, IF/ICC, IP

Cat.No

ADA-16895A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

KDM4B/JMJD2B

Target Synonyms

MRD65; JMJD2B; TDRD14B; KDM4B/JMJD2B

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HCT 116, Mouse brain

Application

ELISA, WB, ChIP, IF/ICC, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KDM4B/JMJD2B (O94953).	Target Species	Human
Immunogen Sequence	PPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWN	Uniprot ID	O94953

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KDM4B/JMJD2B (O94953).

Target Species

Human

Immunogen Sequence

PPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWN

Uniprot ID

O94953

Background Information

Uniprot Id

O94953
Target Species

Human
Target Name

KDM4B
Target Full Name

Lysine-specific demethylase 4B
Target Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Target Subcellular Location

Nucleus.
Target Protein Families

JHDM3 histone demethylase family
Target Synonyms

JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; Jumonji domain containing 2B; Jumonji domain containing protein 2B; Jumonji domain-containing protein 2B; Kdm4b; KDM4B_HUMAN; KIAA0876; Lysine (K) specific demethylase 4B; Lysine demethylase 4B; Lysine-specific demethylase 4B; TDRD14B; Tudor domain containing 14B
Target Background

Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer.

Rabbit anti-Human KDM4B/JMJD2B Monoclonal Antibody

Specifications

Immunogen Information

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