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The antibody against KNSTRN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KNSTRN (NP_001136233.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against KNSTRN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KNSTRN (NP_001136233.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00662A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KNSTRN |
| Target Synonyms | SKAP; HSD11; ROCHIS; C15orf23; TRAF4AF1; KNSTRN | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, A-431 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human KNSTRN (NP_001136233.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y448 | Immunogen Sequence |
Uniprot Id
Q9Y448
Target Species
Human
Target Name
KNSTRN
Target Full Name
Small kinetochore-associated protein
Target Function
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences
Target Involvement
Cutaneous squamous cell carcinomas (SCC): A malignancy of the skin. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Disease susceptibility is associated with variations affecting the gene represented in this entry. Variant Phe-24 appears specific for UV-associated malignancies (PubMed:25194279).
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
Target Tissue Specificity
Widely expressed, including in skin.
Target Synonyms
KNSTRN; C15orf23; SKAP; TRAF4AF1; HSD11; Small kinetochore-associated protein; SKAP; Kinetochore-localized astrin-binding protein; Kinastrin; Kinetochore-localized astrin/SPAG5-binding protein; TRAF4-associated factor 1
Target Background
Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma.
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