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Rabbit anti-Human KREMEN2 Polyclonal Antibody

The antibody against KREMEN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04569A

The antibody against KREMEN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-04569A ClonalityPolyclonal
Host SpeciesRabbitTarget NameKREMEN2
Target SynonymsKRM2; KREMEN2FormLiquid
Species ReactivityMouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesRat brain, Mouse brainApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1).Target SpeciesHuman
Immunogen SequenceGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGAUniprot IDQ8NCW0
Background Information
  • Uniprot Id

    Q8NCW0

  • Target Species

    Human

  • Target Name

    KREMEN2

  • Target Full Name

    Kremen protein 2

  • Target Function

    Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.

  • Target Subcellular Location

    Membrane; Single-pass type I membrane protein.

  • Target Synonyms

    Dickkopf receptor 2; KREM2_HUMAN; KREMEN 2; Kremen protein 2; Kremen protein 2 precursor; Kremen2; Kringle containing protein marking the eye and the nose; Kringle containing transmembrane protein 2; Kringle domain containing transmembrane protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; KRM 2; KRM2; MGC10791; MGC16709

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