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The antibody against LTBP3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1004-1303 of human LTBP3 (NP_001123616.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LTBP3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1004-1303 of human LTBP3 (NP_001123616.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of Rat uterus, using LTBP3 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 45s.
| Cat.No | ADA-10070A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LTBP3 |
| Target Synonyms | DASS; LTBP2; LTBP-3; STHAG6; pp6425; GPHYSD3; LTBP3 | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat uterus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1004-1303 of human LTBP3 (NP_001123616.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NS15 | Immunogen Sequence |
Uniprot Id
Q9NS15
Target Species
Human
Target Name
LTBP3
Target Full Name
Latent-transforming growth factor beta-binding protein 3
Target Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Target Involvement
Dental anomalies and short stature (DASS)
Target Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix.
Target Protein Families
LTBP family
Target Tissue Specificity
Isoform 2: Expressed prominently in heart, skeletal muscle, prostate, testis, small intestine and ovary. Isoform 1: Strongly expressed in pancreas and liver.
Target Synonyms
LTBP3; Latent-transforming growth factor beta-binding protein 3; LTBP-3
Target Background
The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.
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