Rabbit anti-Human MAP1LC3C Polyclonal Antibody

The antibody against MAP1LC3C was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human MAP1LC3C (NP_001004343.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09077A

Number

Cat.No	ADA-09077A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	MAP1LC3C
Target Synonyms	LC3C; ATG8J; MAP1LC3C	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, HepG2, NCI-H460, OVCAR3, Rat lung	Application	ELISA, WB, IHC-P

Cat.No

ADA-09077A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

MAP1LC3C

Target Synonyms

LC3C; ATG8J; MAP1LC3C

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, HepG2, NCI-H460, OVCAR3, Rat lung

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human MAP1LC3C (NP_001004343.1).	Target Species	Human
Immunogen Sequence	MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL	Uniprot ID	Q9BXW4

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human MAP1LC3C (NP_001004343.1).

Target Species

Human

Immunogen Sequence

MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL

Uniprot ID

Q9BXW4

Background Information

Uniprot Id

Q9BXW4
Target Species

Human
Target Name

MAP1LC3C
Target Full Name

Microtubule-associated protein 1 light chain 3 gamma
Target Function

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
Target Subcellular Location

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.
Target Protein Families

ATG8 family
Target Tissue Specificity

Most abundant in placenta, lung and ovary.
Target Research Area

Cancer
Target Synonyms

ATG8J; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; LC3 like protein 2; MAP1 light chain 3 like protein 2; MAP1 light chain 3 like protein 3; MAP1 light chain 3-like protein 3; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light chain 3 C; MAP1LC3C; Microtubule-associated protein 1 light chain 3 gamma; Microtubule-associated proteins 1A/1B light chain 3C; MLP3C_HUMAN
Target Background

Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).

Rabbit anti-Human MAP1LC3C Polyclonal Antibody

Specifications

Immunogen Information

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