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The antibody against MAP4K5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-480 of human MAP4K5 (NP_006566.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against MAP4K5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-480 of human MAP4K5 (NP_006566.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of U2OS cells using MAP4K5 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
| Cat.No | ADA-00121A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAP4K5 |
| Target Synonyms | KHS; GCKR; KHS1; MAPKKKK5; MAP4K5 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 300-480 of human MAP4K5 (NP_006566.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | HAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK | Uniprot ID | Q9Y4K4 |
Uniprot Id
Q9Y4K4
Target Species
Human
Target Name
MAP4K5
Target Full Name
Mitogen-activated protein kinase kinase kinase kinase 5
Target Function
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Target Tissue Specificity
Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.
Target Synonyms
MAP4K5; Mitogen-activated protein kinase kinase kinase kinase 5; EC 2.7.11.1; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
Target Background
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
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