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The antibody against MICU2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200-300 of human MICU2 (NP_689939.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MICU2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200-300 of human MICU2 (NP_689939.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11005A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MICU2 |
| Target Synonyms | EFHA1; 1110008L20Rik; MICU2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, U-87MG | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MICU2 (NP_689939.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | TNETGYQEAIVKEPEIN | Uniprot ID | Q8IYU8 |
Uniprot Id
Q8IYU8
Target Species
Human
Target Name
MICU2
Target Full Name
Calcium uptake protein 2, mitochondrial
Target Function
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
Target Subcellular Location
Mitochondrion intermembrane space.
Target Protein Families
MICU1 family, MICU2 subfamily
Target Synonyms
1110008L20Rik; EF hand domain containing family member A1; EF hand domain family A1; EF hand domain family member A1; EF-hand domain-containing family member A1; EFHA1; EFHA1 EF hand domain family member A1; EFHA1_HUMAN; FLJ25016; FLJ34588; Smhs2 homolog
Target Background
Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex.
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